Comparing Admission Control Architectures for Real-Time Ethernet

Industry 4.0 and Autonomous Driving are emerging resource-intensive distributed application domains that deal with open and evolving environments. These systems are subject to stringent resource, timing, and other non-functional constraints, as well as frequent reconfiguration. Thus, real-time behavior must not preclude operational flexibility. This combination is motivating ongoing efforts within the Time Sensitive Networking (TSN) standardization committee to define admission control mechanisms for Ethernet. Existing mechanisms in TSN, like those of AVB, its predecessor, follow a distributed architecture that favors scalability. Conversely, the new mechanisms envisaged for TSN (IEEE 802.1Qcc) follow a (partially) centralized architecture, favoring short reconfiguration latency. This paper shows the first quantitative comparison between distributed and centralized admission control architectures concerning reconfiguration latency. Here, we compare AVB against a dynamic real-time reconfigurable Ethernet technology with centralized management, namely HaRTES. Our experiments show a significantly lower latency using the centralized architecture. We also observe the dependence of the distributed architecture in the end nodes' performance and the benefit of having a protected channel for the admission control transactions.This work was supported in part by the Spanish Agencia Estatal de Investigación (AEI), in part by the Fondo Europeo de Desarrollo Regional (FEDER) [AEI/FEDER, Unión Europea (UE)] under Grant TEC2015-70313-R, in part by the European Regional Development Fund (FEDER) through the Operational Programme for Competitivity and the Internationalization of Portugal 2020 Partnership Agreement (PRODUTECH-SIF) under Grant POCI-01-0247-FEDER-024541, and in part by the Research Centre Instituto de Telecomunicações under Grant UID/EEA/50008/2013.info:eu-repo/semantics/publishedVersio

Exome sequencing in large, multiplex bipolar disorder families from Cuba.

Bipolar disorder (BD) is a major psychiatric illness affecting around 1% of the global population. BD is characterized by recurrent manic and depressive episodes, and has an estimated heritability of around 70%. Research has identified the first BD susceptibility genes. However, the underlying pathways and regulatory networks remain largely unknown. Research suggests that the cumulative impact of common alleles with small effects explains only around 25-38% of the phenotypic variance for BD. A plausible hypothesis therefore is that rare, high penetrance variants may contribute to BD risk. The present study investigated the role of rare, nonsynonymous, and potentially functional variants via whole exome sequencing in 15 BD cases from two large, multiply affected families from Cuba. The high prevalence of BD in these pedigrees renders them promising in terms of the identification of genetic risk variants with large effect sizes. In addition, SNP array data were used to calculate polygenic risk scores for affected and unaffected family members. After correction for multiple testing, no significant increase in polygenic risk scores for common, BD-associated genetic variants was found in BD cases compared to healthy relatives. Exome sequencing identified a total of 17 rare and potentially damaging variants in 17 genes. The identified variants were shared by all investigated BD cases in the respective pedigree. The most promising variant was located in the gene SERPING1 (p.L349F), which has been reported previously as a genome-wide significant risk gene for schizophrenia. The present data suggest novel candidate genes for BD susceptibility, and may facilitate the discovery of disease-relevant pathways and regulatory networks